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Peptidyss® is made from fish by-products collected in local fisheries.

[New Scientific Publication] Peptidyss® reduces stress hormone secretion and modulates stress-responsive gene expression

As Elodie mentioned during her speech at Nutriform, “Stress response is a natural reaction from our body when facing a stressful situation: our body produces a sequence of chemical messages which starts in hypothalamus, goes to pituitary gland and finally to adrenal cortex to produce a hormone called cortisol. This hormone makes our cells react to induce an action. Running away from danger to keep being alive for example. An interesting point is the negative feedback that appears when the stress reaction is over: it helps our body returning to a normal level of stress.”

Elodie speech at Nutriform Business Day 2020, Saint-Raphaël

Even though stress can potentially save your life when facing a danger, too much of it may lead to troubles such as sleeping or memory disorders or even more serious pathology or disease like anxiety, obesity etc…

Indeed, last September we mentionned the figures related to stress which are not so good. And the Covid crisis is not helping us to manage our stress!

Hopefully there are natural solutions to help us in these hard times. Anne-Laure DINEL, our Research Scientist partner based in NutriNeuro Lab, Manager of Nutribrain at the Université de Bordeaux explains the effects of Peptidyss® on our brain (and stress management).

Why is too much stress dangerous for our health?

Several studies demonstrated that a chronic stress can induce a larger and prolonged elevation of stress hormone (glucocorticoids) level. This can consequently impaire hippocampal function. Hippocampus is a cerebral structure highly implicated in several major functions as cognitive function. 

In humans, many studies have reported a link between elevated basal corticosteroid levels and some forms of depression or alteration of cognition. Moreover, stress can alter sleep quality. Consequently, it is important to improve stress management to prevent these negative effects of daily life stress.

The results of the 2019 study showed that Peptidyss® modulates the stress hormone. Does it mean that Peptidyss® helps to reduce the negative effects of stress?

In this study, we try to demonstrate that a supplementation with Peptidyss® can improve stress reactivity. After an acute but moderate stress, we measure the level of stress hormone in plasma. Our results demonstrated that 20 minutes after stress induction, Peptidyss® supplementation decreased the level of corticosterone compared to the control group without blocking the stress response that is necessary to cope with stress and adversity. This first evidence demonstrates that Peptidyss® can reduce the deleterious effects of stress.

You analysed the modulation of stress expression in 93 genes known as stress-responsive. What does this analysis show?

It is now well described that one mechanism of action of stress hormone in the brain is its genomic effect, resulting in the modulation of genes called stress-responsive genes. We evaluated the impact of Peptidyss® supplementation on some of stress-responsive genes expression in specific cerebral structures (hippocampus, prefrontal cortex and amygdala) involved in the regulation of stress, cognition and mood disorders. 

We demonstrated that Peptidyss® supplementation modulated genes associated to stress pathway. In a matter of fact, the upregulation of these specific genes can act as a primer of the corticosteroid signaling.

Moreover, Peptidyss® supplementation also regulated one of the core genes of the circadian clock playing a critical role in sleep, especially in familial advanced sleep phase syndrome. As stress and sleep are connected and codependent, the upregulation of this gene by Peptidyss® supplementation could participate to its anxiolytic effect.

Peptidyss® supplementation also modulated the expression of genes involved in mitochondrial signaling that can contribute to the biological embedding of psychological states like stress.

Taken together, those results demonstrated that Peptidyss® can be an innovative strategy to regulate and manage stress. 

Is there any effect that would be interesting to look deeper into?

Interestingly, this study confirms that bioactive peptides play a critical role in regulating various biological processes and start to be considered as a “hidden treasure” of drug candidates. Moreover, this study opens the way to other beneficial impacts of Peptidyss® supplementation.

We demonstrated that Peptidyss® modulated SIRT2 expression in the hippocampus but also in the prefrontal cortex. SIRT2 plays diverse roles in cellular metabolism and ageing and the connection between SIRT2 and neurological disorders is now well established. The potential of SIRT2 as a therapeutic target in neurodegenerative diseases started to be studied. The upregulation of SIRT2 by Peptidyss® in basal and stress conditions could be of great interest to prevent neurodegenerative alterations and should be further investigated.

To put it in a nutshell, this second study showed that Peptidyss® supplementation significantly decreases corticosterone secretion during a stress and modulates stress-responsive gene expression, which definitely demonstrates Peptidyss® effects on stress management.

In addition, the more detailed study of stress-related gene expression modulation showed that Peptidyss® also has an impact on gene expression modulation implicated in circadian rhythm – with potential new application on sleeping disorders for Peptidyss® – and healthy-aging.

Peptidyss® seems promessful to delay deleterious effects of stress and more particularly sleeping disorders. This trail will be investigated in a complementary clinical study that has been launched recently and for which we should have first results in early 2022.